Article
The association of MEFV gene mutations with the disease risk and severity of systemic juvenile idiopathic arthritis.
Pediatric rheumatology online journal - 12 May 2020
Zhong Linqing, Wang Wei, Li Ji, Ma Mingsheng, Gou Lijuan, Wang Changyan, Yu Zhongxun, Zhang Tiannan, Dong Yanqing, Wei Qijiao, Song Hongmei
Abstract excerpt
BACKGROUND: Systemic juvenile idiopathic arthritis (sJIA) has many clinical features overlapping with familial Mediterranean fever (FMF), which is caused by mutations in MEFV gene. And FMF patients were easily misdiagnosed as sJIA in China. So we speculate that MEFV is critical genetic background for sJIA and influences patients' severity. In this study, we aim to figure out whether MEFV mutations are risk factor...
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