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Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion

12 May 2020

Abstract excerpt

BACKGROUND: The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at the maternal fetal interface, while the mechanism remains unclear. METHODS: Autophagy levels in the villi of normal and recurrent spontaneous abortion (RSA) patients were detected by...

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PMID: 32398034
DOI: 10.1186/s12964-020-00579-w

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