Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors.

doi:10.1158/1535-7163.MCT-19-1060

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Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors.

Molecular cancer therapeutics - 1 Jul 2020

Davis Andrew A, Iams Wade T, Chan David, Oh Michael S, Lentz Robert W, Peterman Neil, Robertson Alex, Shah Abhik, Srivas Rohith, Wilson Timothy J, Lambert Nicole J, George Peter S, Wong Becky, Wood Haleigh W, Close Jason C, Tezcan Ayse, Nesmith Ken, Tezcan Haluk, Chae Young Kwang

Abstract excerpt

Treatment response assessment for patients with advanced solid tumors is complex and existing methods require greater precision. Current guidelines rely on imaging, which has known limitations, including the time required to show a deterministic change in target lesions. Serial changes in whole-genome (WG) circulating tumor DNA (ctDNA) were used to assess response or resistance to treatment early in the treatment...

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Identifiers

PMID: 32371589
DOI: 10.1158/1535-7163.MCT-19-1060
PMCID: PMC8142024

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