Article
Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type I and Literature Review.
Journal of pediatric hematology/oncology - 1 May 2021
Cabrera Trevor B, Wang Wei, Yedururi Sireesha, Slopis John M, Steiner Raphael E, Rytting Michael E, Cuglievan Branko
Abstract excerpt
Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by café-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies....
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