Article
A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants.
Cancer research - 1 Jul 2020
Chao Jesse T, Hollman Rocio, Meyers Warren M, Meili Fabian, Matreyek Kenneth A, Dean Pamela, Fowler Douglas M, Haas Kurt, Roskelley Calvin D, Loewen Christopher J R
Abstract excerpt
As sequencing becomes more economical, we are identifying sequence variations in the population faster than ever. For disease-associated genes, it is imperative that we differentiate a sequence variant as either benign or pathogenic, such that the appropriate therapeutic interventions or surveillance can be implemented. PTEN is a frequently mutated tumor suppressor that has been linked to the PTEN hamartoma tumor...
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