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Article

A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

1 May 2020

Abstract excerpt

The flaviviruses pose serious threats to human health. Being a natural fusion of a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP), NS5 is the most conserved flavivirus protein and an important antiviral target. Previously reported NS5 structures represented by those from the Japanese encephalitis virus (JEV) and Dengue virus serotype 3 (DENV3) exhibit two apparently different global...

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PMID: 32357182
DOI: 10.1371/journal.ppat.1008484

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