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PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway

25 Apr 2020

Abstract excerpt

BACKGROUND: This article reports the effects of proenkephalin (PENK) on osteosarcoma (OS) cell migration. METHODS: A Gene Expression Omnibus (GEO) dataset was used to identify differentially expressed genes (DEGs) in OS tumor samples and normal human osteoblasts. Tumor tissue and adjacent normal tissue were collected from 40 OS patients. MG63 cells were transfected with si-PENK. Transwell migration assays and...

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PMID: 32334633
DOI: 10.1186/s13018-020-01679-6

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