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LncRNA NEAT1 promotes proliferation of chondrocytes via down‐regulation of miR‐16‐5p in osteoarthritis

20 Apr 2020

Abstract excerpt

BACKGROUND: Non-coding RNAs are endogenous regulators of gene expression that have been implicated in the pathogenesis of various diseases, including osteoarthritis (OA). Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) and miR-16-5p are up-regulated in OA tissues; however, their functions have not been clarified. METHODS: Chondrocyte ATDC5 was used as a cell model. NEAT1 overexpression and...

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PMID: 32307795
DOI: 10.1002/jgm.3203

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