Article
Pulmonary Alveolar Microlithiasis.
Seminars in respiratory and critical care medicine - 1 Apr 2020
Shaw Brian M, Shaw Steven D, McCormack Francis X
Abstract excerpt
Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive disorder that is caused by mutations in SCL34A2 that encodes for the type IIb sodium-dependent phosphate cotransporter (Npt2b). The loss of Npt2b transporter function from alveolar epithelial cells results in failure to export inorganic phosphate from the alveolar lining fluid, which then accumulates, binds to calcium, and forms hydroxyapatite...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.