Article
Plasmodium vivax HAP2/GCS1 gene exhibits limited genetic diversity among parasite isolates from the Greater Mekong Subregion.
Parasites & vectors - 7 Apr 2020
Li Danni, Yu Chunyun, Guo Jian, Wang Yazhou, Zhao Yan, Wang Lin, Soe Myat Thu, Feng Hui, Kyaw Myat Phone, Sattabongkot Jetsumon, Jiang Lubin, Cui Liwang, Zhu Xiaotong, Cao Yaming
Abstract excerpt
BACKGROUND: Antigens expressed in sexual stages of the malaria parasites are targets of transmission-blocking vaccines (TBVs). HAP2/GCS1, a TBV candidate, is critical for fertilization in Plasmodium. Here, the genetic diversity of PvHAP2 was studied in Plasmodium vivax parasite populations from the Greater Mekong Subregion (GMS). METHODS: Plasmodium vivax clinical isolates were collected in clinics from the...
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