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Article

MYC copy number and mRNA expression in chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chornobyl NPP accident.

Experimental oncology - 1 Mar 2020

Bilous N, Abramenko I, Chumak A, Dyagil I, Martina Z

Abstract excerpt

Some clinical and biological features indicating an unfavorable course of the disease were found in ionizing radiation (IR) - related chronic lymphocytic leukemia (CLL) patients. The MYC proto-oncogene is considered to contribute to CLL pathogenesis. Increased MYC copy number is associated with poor prognosis in CLL. AIM: To investigate the frequency of MYC gene copy number amplification in IR-exposed CLL...

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Identifiers

PMID: 32231192
DOI: 10.32471/exp-oncology.2312-8852.vol-42-no-1.14214

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