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Article

Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.

Scientific reports - 20 Mar 2020

Ye Feng, Liu Jia, Wang Hanzhi, Chen Xiaojing, Cheng Qi, Chen Huaizeng

Abstract excerpt

Genetic polymorphisms of NEIL1 and NEIL2 maybe change protein function, and increased carcinogenesis. In this study, seven NEIL1 SNPs and three NEIL2 SNPs were selected. 400 CSCCs, 400 CIN III, and 1200 normal healthy controls were genotyped by mismatch amplification PCR. mRNA and protein expression of NEIL2 was measured in 92 freshly-obtained CSCC tumor tissues. The association between homozygote CC genotype of...

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PMID: 32198476
DOI: 10.1038/s41598-020-62040-9
PMCID: PMC7083954

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