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Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2020

Feng Bohai, Shen Ying, Pastor Hostench Xavier, Bieg Matthias, Plath Michaela, Ishaque Naveed, Eils Roland, Freier Kolja, Weichert Wilko, Zaoui Karim, Hess Jochen

Abstract excerpt

PURPOSE: Malignant progression exhibits a tightly orchestrated balance between immune effector response and tolerance. However, underlying molecular principles that drive the establishment and maintenance of the tumor immune phenotype remain to be elucidated. EXPERIMENTAL DESIGN: We trained a novel molecular classifier based on immune cell subsets related to programmed death-ligand 1 (PD-L1) and interferon γ...

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Identifiers

PMID: 32161122
DOI: 10.1158/1078-0432.CCR-19-3997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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