Article
Performance of Metagenomic Next-Generation Sequencing for the Diagnosis of Viral Meningoencephalitis in a Resource-Limited Setting
8 Feb 2020
Abstract excerpt
BACKGROUND: Meningoencephalitis is a devastating disease worldwide. Current diagnosis fails to establish the cause in ≥50% of patients. Metagenomic next-generation sequencing (mNGS) has emerged as pan-pathogen assays for infectious diseases diagnosis, but few studies have been conducted in resource-limited settings. METHODS: We assessed the performance of mNGS in the cerebrospinal fluid (CSF) of 66 consecutively...
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