Insufficient CD100 shedding contributes to suppression of CD8+ T‐cell activity in non‐small cell lung cancer

Abstract excerpt

Summary CD100 is an immune semaphorin constitutively expressed on T‐cells. Matrix metalloproteinase (MMP) is an important mediator of membrane‐bound CD100 (mCD100) cleavage to generate soluble CD100 (sCD100), which has immunoregulatory activity in immune cell responses. The aim of the study was to investigate the level and role of sCD100 and mCD100 in modulating CD8+ T‐cell function in non‐small cell lung cancer...

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