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Article

The role of T-regulatory cells in pregnancy and cancer

1 Nov 2007

Abstract excerpt

The acceptance of paternally-derived alloantigens during pregnancy and escape from host immunosurveillance by cancer are based on similar immunological mechanisms. Among them both natural and peripherally-induced T CD4+ CD25+ Foxp3+ and Tr1 regulatory cells (Tregs) play important role. Interactions of Tregs with other immunocytes including dendritic cells, mechanisms of Tregs recruitment and their suppressive...

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PMID: 17981709
DOI: 10.2741/2841

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