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Metabolism-associated genome-wide epigenetic changes in bovine oocytes during early lactation

11 Feb 2020

Abstract excerpt

Dietary intake in early lactating cows is outmatched by milk production. These cows experience a negative energy balance, resulting in a distinct blood metabolism and poor reproductive function due to impaired ovulation and increased embryo loss. We hypothesize that oocytes from lactating cows undergoing transient metabolic stress exhibit a different epigenetic profile crucial for developmental competence. To...

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PMID: 32047242
DOI: 10.1038/s41598-020-59410-8

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