Article
Tubulin-binding cofactor E-like (TBCEL), the protein product of the mulet gene, is required in the germline for the regulation of inter-flagellar microtubule dynamics during spermatid individualization.
Biology open - 26 Feb 2020
Fabrizio James J, Rollins Janet, Bazinet Christopher W, Wegener Stephanie, Koziy Iryna, Daniel Rachel, Lombardo Vincent, Pryce Dwaine, Bharrat Kavita, Innabi Elissa, Villanobos Marielle, Mendoza Gabriela, Ferrara Elisa, Rodway Stephanie, Vicioso Matthew, Siracusa Victoria, Dailey Erin, Pronovost Justin, Innabi Simon, Patel Vrutant, DeSouza Nicole, Quaranto Danielle, Niknejad Amir
Abstract excerpt
Individual sperm cells are resolved from a syncytium during late step of spermiogenesis known as individualization, which is accomplished by an Individualization Complex (IC) composed of 64 investment cones. mulet encodes Tubulin-binding cofactor E-like (TBCEL), suggesting a role for microtubule dynamics in individualization. Indeed, a population of ∼100 cytoplasmic microtubules fails to disappear in mulet mutant...
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