Article
Identification of a C3'-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth.
Bioorganic & medicinal chemistry letters - 15 Mar 2020
Labbé Marc-Olivier, Collins Laura, Lefebvre Carole-Anne, Maharsy Wael, Beauregard Janie, Dostie Starr, Prévost Michel, Nemer Mona, Guindon Yvan
Abstract excerpt
A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either wild-type (BxPC3) or G12V KRAS (Capan2) mutations. A promising compound was shown to have significantly greater efficacy in the Capan2 cell line as compared to...
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