Article
Post-Essential Thrombocythemia Myelofibrosis and Multiple Isodicentric Y Chromosomes: A Unique Case among a Rare Association.
Cytogenetic and genome research - 1 Jan 2020
Dahlen Eric, Sarghi Sinziana I, Renosi Florian, Ferrand Christophe, Collonge-Rame Marie-Agnes, Kuentz Paul
Abstract excerpt
Multiple isodicentric Y chromosomes [idic(Y)] is a rare cytogenetic abnormality, most exclusively described in constitutional karyotypes. Only recently has this entity been reported in hematologic neoplasms such as myeloid disorders, albeit these cases remain very scarce. The possible involvement of increasing copies of potential proto-oncogenes located on the multiple idic(Y) led to consider one of them, CRLF2,...
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