Article
Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia.
Journal of cellular and molecular medicine - 1 Mar 2020
Weisberg Ellen, Meng Chengcheng, Case Abigail E, Tiv Hong L, Gokhale Prafulla C, Buhrlage Sara J, Yang Jing, Liu Xiaoxi, Wang Jinhua, Gray Nathanael, Adamia Sophia, Sattler Martin, Stone Richard, Griffin James D
Abstract excerpt
Recently, several targeted agents have been developed for specific subsets of patients with acute myeloid leukaemia (AML), including midostaurin, the first FDA-approved FLT3 inhibitor for newly diagnosed patients with FLT3 mutations. However, in the initial Phase I/II clinical trials, some patien...
Topics
- Aniline Compounds
- Animals
- Antineoplastic Agents
- Apoptosis
- Benzimidazoles
- Benzothiazoles
- Cell Line, Tumor
- Cell Proliferation
- Drug Synergism
- Gene Expression Regulation, Neoplastic
- Humans
- Leukemia, Myeloid, Acute
- Mice