Article
Molecular characterisation of oncogenic urothelial mosaic mutations in patients with extensive keratinocytic epidermal naevi.
Journal of medical genetics - 1 Sept 2020
Gadea Alejandra, Hernández-Muñoz Inmaculada, Vicente Asunción, Andrades Evelyn, García-Calvente Miriam, Camacho Laura, Fernandez-Rodríguez Conchi, Bellosillo Beatriz, Pujol Ramon, Toll Agustín
Abstract excerpt
Background: Keratinocytic epidermal naevi (KENs) are congenital benign skin mosaic lesions that share common mutations with some subsets of urothelial carcinomas. Moreover, several patients with extensive KEN who also developed urothelial carcinomas at young ages have been reported. Thus, patients with extensive KEN may harbour mosaic urothelial oncogenic mutations that would favour the early development of...
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