Article
Kaposiform hemangioendothelioma and tufted angioma - (epi)genetic analysis including genome-wide methylation profiling.
Annals of diagnostic pathology - 1 Feb 2020
Ten Broek Roel W, Koelsche Christian, Eijkelenboom Astrid, Mentzel Thomas, Creytens David, Vokuhl Christian, van Gorp Joost M, Versleijen-Jonkers Yvonne M, van der Vleuten Carine J, Kemmeren Patrick, van de Geer Ellen, von Deimling Andreas, Flucke Uta
Abstract excerpt
Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular condition of childhood and is clinicopathologically related to tufted angioma (TA), a benign skin lesion. Due to their rarity molecular data are scarce. We investigated 7 KHE and 3 TA by comprehensive mutational analysis and genome-wide methylation profiling and compared the clustering, also with vascular malformations. Lesions were from 7...
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