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Article

Expression of Prox1, Lymphatic Endothelial Nuclear Transcription Factor, in Kaposiform Hemangioendothelioma and Tufted Angioma

21 Oct 2010

Abstract excerpt

Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare tumors mainly occurring in early childhood. Our recent results showed that ectopic overexpression of human Prox1 gene, a lymphatic endothelial nuclear transcription factor, promoted an aggressive behavior in 2 murine models of KHE. This dramatic Prox1-induced phenotype prompted us to investigate immunohistochemical staining pattern of Prox1,...

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PMID: 20975337
DOI: 10.1097/pas.0b013e3181f6076f

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