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Sighting acute myocardial infarction through platelet gene expression

20 Dec 2019

Abstract excerpt

Acute myocardial infarction is primarily due to coronary atherosclerotic plaque rupture and subsequent thrombus formation. Platelets play a key role in the genesis and progression of both atherosclerosis and thrombosis. Since platelets are anuclear cells that inherit their mRNA from megakaryocyte precursors and maintain it unchanged during their life span, gene expression profiling at the time of an acute...

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PMID: 31863085
DOI: 10.1038/s41598-019-56047-0

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