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Article

Deficient autophagy in epithelial stem cells drives aging in the freshwater cnidarian Hydra.

Development (Cambridge, England) - 23 Jan 2020

Tomczyk Szymon, Suknovic Nenad, Schenkelaars Quentin, Wenger Yvan, Ekundayo Kazadi, Buzgariu Wanda, Bauer Christoph, Fischer Kathleen, Austad Steven, Galliot Brigitte

Abstract excerpt

Hydra possesses three distinct stem cell populations that continuously self-renew and prevent aging in Hydra vulgaris However, sexual animals from the H. oligactis cold-sensitive strain Ho_CS develop an aging phenotype upon gametogenesis induction, initiated by the loss of interstitial stem cells. Animals stop regenerating, lose their active behaviors and die within 3 months. This phenotype is not observed in the...

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Identifiers

PMID: 31862842
DOI: 10.1242/dev.177840
PMCID: PMC6983715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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