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Article

Sequencing detects human papillomavirus in some apparently HPV-negative invasive cervical cancers.

The Journal of general virology - 1 Mar 2020

Arroyo Mühr Laila Sara, Lagheden Camilla, Eklund Carina, Lei Jiayao, Nordqvist-Kleppe Sara, Sparén Pär, Sundström Karin, Dillner Joakim

Abstract excerpt

Introduction. Cervical cancer is caused by human papillomavirus (HPV), but some cases may test HPV-negative. We previously tested 2850 Swedish cases and found that 394/2850 (13.8 %) cases tested HPV DNA-negative by PCR. Sequencing is the most thorough method to assess HPV status.Aim. We wished to assess whether deep sequencing might detect HPV sequences among these HPV-negative cervical cancer specimens, and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31859615
DOI: 10.1099/jgv.0.001374

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