Article
Evidence of genomic information and structural restrictions of HIV-1 PR and RT gene regions from individuals experiencing antiretroviral virologic failure.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2020
de Carvalho Lima Elidamar Nunes, Lima Rodrigo Sucupira Andrade, Piqueira José Roberto Castilho, Sucupira Maria Cecília, Camargo Michelle, Galinskas Juliana, Diaz Ricardo Sobhie
Abstract excerpt
OBJECTIVES: This study analyzed Protease-PR and Reverse Transcriptase-RT HIV-1 genomic information entropy metrics among patients under antiretroviral virologic failure, according to the numbers of virologic failures or resistance mutations. METHODS: For this purpose, we used genomic sequences from PR and RT of HIV-1 from a cohort of chronic patients followed up at São Paulo Hospital. RESULTS: Informational...
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