Article
Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias.
Blood advances - 10 Dec 2019
Sridharan Ashwin, Schinke Carolina D, Georgiev George, Da Silva Ferreira Mariana, Thiruthuvanathan Victor, MacArthur Ian, Bhagat Tushar D, Choudhary Gaurav S, Aluri Srinivas, Chen Jiahao, Pradhan Kith, Xia Yu, Panjikaran Maya, Sims Gregory, Bhagat Chirag K, Bender Ryan, Keeler Lauryn, Graber Armin, Heuck Christoph, Fletcher Frederick A, Alapat Daisy, Weinhold Niels, Johnson Sarah K, Wickrema Amittha, Barlogie Bart, Morgan Gareth J, Shastri Aditi, Steidl Ulrich, Will Britta, Verma Amit
Abstract excerpt
Therapy-related acute myeloid leukemia and myelodysplastic syndromes (t-AML/t-MDS) are secondary hematologic malignancies associated with poor prognosis, warranting insights into their predisposing conditions and cells of origin. We identified patients with myeloma who developed t-AML/t-MDS and analyzed their stem and progenitor cells collected years before the onset of secondary disease. We demonstrate that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.