Article
Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study.
The pharmacogenomics journal - 1 Jun 2020
Smit Roelof A J, Trompet Stella, Leong Aaron, Goodarzi Mark O, Postmus Iris, Warren Helen, Theusch Elizabeth, Barnes Michael R, Arsenault Benoit J, Li Xiaohui, Feng QiPing, Chasman Daniel I, Cupples L Adrienne, Hitman Graham A, Krauss Ronald M, Psaty Bruce M, Rotter Jerome I, Cessie Saskia le, Stein C Michael, Jukema J Wouter
Abstract excerpt
It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D might cause greater proportional statin-induced LDL-C lowering. Using summary-level statistics from the Genomic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.