Article
Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus.
PLoS neglected tropical diseases - 1 Dec 2019
Marconcini Michele, Hernandez Luis, Iovino Giuseppe, Houé Vincent, Valerio Federica, Palatini Umberto, Pischedda Elisa, Crawford Jacob E, White Bradley J, Lin Teresa, Carballar-Lejarazu Rebeca, Ometto Lino, Forneris Federico, Failloux Anna-Bella, Bonizzoni Mariangela
Abstract excerpt
Current knowledge of the piRNA pathway is based mainly on studies on Drosophila melanogaster where three proteins of the Piwi subclade of the Argonaute family interact with PIWI-interacting RNAs to silence transposable elements in gonadal tissues. In mosquito species that transmit epidemic arboviruses such as dengue and chikungunya viruses, Piwi clade genes underwent expansion, are also expressed in the soma and...
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