Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries.

doi:10.1016/j.tibtech.2019.11.003

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Article

Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries.

Trends in biotechnology - 1 Jan 2020

Timmermans Marshall L, Ross Avena C

Abstract excerpt

The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics generates a metabolic clean slate for the detection and/or isolation of new and less plentiful...

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PMID: 31785780
DOI: 10.1016/j.tibtech.2019.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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