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A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair

25 Oct 2019

Abstract excerpt

Despite the well-documented capacity of embryonic stem cells (ESCs) to differentiate into cardiomyocytes, transplantation of ESCs or ESC-derived cells is plagued by several formidable problems, including graft rejection, arrhythmias, and potential risk of teratomas. Life-long immunosuppression is a disease in itself. Transplantation of human ESC-derived cells in primates causes life-threatening arrhythmias, and...

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PMID: 31778154
DOI: 10.1093/eurheartj/ehz787

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