Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization

22 Nov 2019

Abstract excerpt

The Spinal Muscular Atrophy (SMA) gene SMN was recently duplicated (SMN1 and SMN2) in higher primates. Furthermore, invasion of the locus by repetitive elements almost doubled its size with respect to mouse Smn, in spite of an almost identical protein-coding sequence. Herein, we found that SMN ranks among the human genes with highest density of Alus, which are evolutionary conserved in primates and often occur in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular RNAs in diseases
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31777926
DOI: 10.1093/nar/gkz1117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularizationPMID 31777926Read ↗

The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy.Semantic proximity Read ↗

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent intronsSemantic proximity Read ↗

Transcriptome- and proteome-wide effects of a circular RNA encompassing four early exons of the spinal muscular atrophy genesSemantic proximity Read ↗

Sm-site containing mRNAs can accept Sm-rings and are downregulated in Spinal Muscular AtrophySemantic proximity Read ↗

Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.Semantic proximity Read ↗

The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP ProteinsSemantic proximity Read ↗

Evolving concepts on human SMN pre-mRNA splicing.Semantic proximity Read ↗

A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA SplicingSemantic proximity Read ↗

SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophySemantic proximity Read ↗

Comprehensive Analysis of Retrotransposon Insertions within the Survival Motor Neuron Genes Involved in Spinal Muscular AtrophySemantic proximity Read ↗

Whole-transcriptome sequencing in neural and non-neural tissues of a mouse model identifies miR-34a as a key regulator in SMA pathogenesisSemantic proximity Read ↗

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.