Article
Significance of RAS mutations in pulmonary metastases of patients with colorectal cancer.
International journal of clinical oncology - 1 Apr 2020
Igarashi Takamichi, Shimizu Kimihiro, Usui Kengo, Yokobori Takehiko, Ohtaki Yoichi, Nakazawa Seshiru, Obayashi Kai, Yajima Toshiki, Nobusawa Sumihito, Ohkawa Takahiro, Katoh Ryuji, Motegi Yoko, Ogawa Hiroomi, Harimoto Norifumi, Ichihara Tatsuo, Mitani Yasumasa, Yokoo Hideaki, Mogi Akira, Shirabe Ken
Abstract excerpt
BACKGROUND: RAS/BRAF mutations of colorectal cancer (CRC) play a crucial role in carcinogenesis and cancer progression and need to be considered for the therapeutic strategy choice. We used next-generation-sequencing (NGS) technology to assess RAS/BRAF mutation differences between primary CRC and corresponding pulmonary metastases (PMs). METHODS: We examined the mutation statuses of the KRAS 12/13/61/146, NRAS...
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