Article
Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation.
Oncogene - 1 Feb 2020
Lefort Sylvain, Tan Susanna, Balani Sneha, Rafn Bo, Pellacani Davide, Hirst Martin, Sorensen Poul H, Eaves Connie J
Abstract excerpt
High YAP activity is associated with poor prognosis human breast cancers, but its role during the initial stage of mammary cell transformation is unknown. To address this question, we designed experiments that exploit the ability of KRASG12D-transduced subsets of freshly isolated normal human mammary cells to form invasive tumors rapidly and efficiently when transplanted into immunodeficient mice. Initial...
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