Article
Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer.
Scientific reports - 26 Nov 2019
Bao Jie, Walliander Margarita, Kovács Ferenc, Nagaraj Ashwini S, Hemmes Annabrita, Sarhadi Virinder Kaur, Knuutila Sakari, Lundin Johan, Horvath Peter, Verschuren Emmy W
Abstract excerpt
To facilitate analysis of spatial tissue phenotypes, we created an open-source tool package named 'Spa-RQ' for 'Spatial tissue analysis: image Registration & Quantification'. Spa-RQ contains software for image registration (Spa-R) and quantitative analysis of DAB staining overlap (Spa-Q). It provides an easy-to-implement workflow for serial sectioning and staining as an alternative to multiplexed techniques. To...
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