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Article

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.

Nature medicine - 1 Dec 2019

Durham Benjamin H, Lopez Rodrigo Estibaliz, Picarsic Jennifer, Abramson David, Rotemberg Veronica, De Munck Steven, Pannecoucke Erwin, Lu Sydney X, Pastore Alessandro, Yoshimi Akihide, Mandelker Diana, Ceyhan-Birsoy Ozge, Ulaner Gary A, Walsh Michael, Yabe Mariko, Petrova-Drus Kseniya, Arcila Maria E, Ladanyi Marc, Solit David B, Berger Michael F, Hyman David M, Lacouture Mario E, Erickson Caroline, Saganty Ruth, Ki Michelle, Dunkel Ira J, Santa-María López Vicente, Mora Jaume, Haroche Julien, Emile Jean-Francois, Decaux Olivier, Geissmann Frederic, Savvides Savvas N, Drilon Alexander, Diamond Eli L, Abdel-Wahab Omar

Abstract excerpt

Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to the BRAF and MEK1 and MEK2 kinases. Currently, however, the developmental origins of histiocytoses in patients are not well understood, and clinically meaningful therapeutic targets outside of BRAF and MEK are undefined. In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that...

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Source

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Identifiers

PMID: 31768065
DOI: 10.1038/s41591-019-0653-6
PMCID: PMC6898787

Genes

BRAF
CSF1R
RET
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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