Article
Regulation of the KCNJ5 gene by SF-1 in the adrenal cortex: Complete genomic organization and promoter function.
Molecular and cellular endocrinology - 5 Feb 2020
Nishikido Ayaka, Okamura Takashi, Nakajima Yasuyo, Ishida Emi, Miyamoto Tomoko, Toki Akiko-Katano, Matsumoto Shunichi, Yoshino Satoshi, Horiguchi Kazuhiko, Saito Tsugumichi, Yamada Eijiro, Ozawa Atsushi, Shimoda Yuki, Oyama Tetsunari, Yamada Masanobu
Abstract excerpt
Activating mutations in the KCNJ5 gene are responsible for the significant number of aldosterone-producing adenomas. To elucidate the molecular mechanisms underlying KCNJ5 expression, we characterized the entire human KCNJ5 gene. The gene spanned approximately 29.8 kb and contained three exons and two introns. The strongest expression of KCNJ5 mRNA was observed in the adrenal gland. The promoter region contained...
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