Article
NMD Takes the Immune Road to NDD.
Neuron - 20 Nov 2019
Kim Eunha, Huh Jun R
Abstract excerpt
Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by triggering aberrant immune activation.
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