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Article

Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications.

Scientific reports - 20 Nov 2019

Meyre David, Andress Edward J, Sharma Tanmay, Snippe Marjolein, Asif Hamza, Maharaj Arjuna, Vatin Vincent, Gaget Stefan, Besnard Philippe, Choquet Hélène, Froguel Philippe, Linton Kenneth J

Abstract excerpt

We sequenced coding regions of the cluster of differentiation 36 (CD36) gene in 184 French individuals of European ancestry presenting simultaneously with type 2 diabetes (T2D), arterial hypertension, dyslipidemia, and coronary heart disease. We identified rare missense mutations (p.Pro191Leu/rs143150225 and p.Ala252Val/rs147624636) in two heterozygous cases. The two CD36 mutation carriers had no family history...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD36 Antigens
Share to Cell Membrane
Share to Coronary Disease
Share to Diabetes Mellitus, Type 2
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Share to Lipoproteins, LDL
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Identifiers

PMID: 31748580
DOI: 10.1038/s41598-019-53388-8
PMCID: PMC6868229

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