Article
Development and validation of a targeted gene sequencing panel for application to disparate cancers.
Scientific reports - 19 Nov 2019
McCabe Mark J, Gauthier Marie-Emilie A, Chan Chia-Ling, Thompson Tanya J, De Sousa Sunita M C, Puttick Clare, Grady John P, Gayevskiy Velimir, Tao Jiang, Ying Kevin, Cipponi Arcadi, Deng Niantao, Swarbrick Alex, Thomas Melissa L, Lord Reginald V, Johns Amber L, Kohonen-Corish Maija, O'Toole Sandra A, Clark Jonathan, Mueller Simon A, Gupta Ruta, McCormack Ann I, Dinger Marcel E, Cowley Mark J
Abstract excerpt
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour's molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on tumours of the head and neck, plus test for utility in liquid biopsy. The final panel designed through...
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