Article
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Journal of medical case reports - 20 Nov 2019
Sasson Sarah C, Corbett Alastair, McLachlan Andrew J, Chen R, Adelstein S A, Riminton Sean, Limaye Sandhya
Abstract excerpt
BACKGROUND: Myotonic dystrophy type 1 is an autosomal dominant disorder characterized by muscle weakness, myotonia, cataracts, and cardiac conduction defects; it is associated with expansions of cytosine-thymine-guanine repeats in the myotonic dystrophy protein kinase. Hypogammaglobulinemia is a lesser known association of myotonic dystrophy type 1 and the underlying pathogenesis of immunoglobulin G depletion...
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