Article
The potential application of human PIG-A assay on azathioprine-treated inflammatory bowel disease patients.
Environmental and molecular mutagenesis - 1 Apr 2020
Cao Yiyi, Wang Xiaolei, Liu Weiying, Feng Nannan, Xi Jing, You Xinyue, Chen Ruixue, Zhang XinYu, Liu Zhanju, Luan Yang
Abstract excerpt
The rodent Pig-a assay has been used extensively as a potential regulatory assay for evaluating the in vivo mutagenicity of test substances. Although the assay can be conducted in different mammalian species, there have been only a few reports describing its use in humans, and rarely in genotoxicant-exposed human populations. In this study, PIG-A mutation frequencies (MFs) were evaluated in 36 azathioprine (AZA;...
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