Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2.

doi:10.1093/glycob/cwz097

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Article

Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2.

Glycobiology - 20 Apr 2020

Xu Ling, Liu Fenglin, Li Can, Li Shuxuan, Wu Hao, Guo Bao, Gu Jianxin, Wang Lan

Abstract excerpt

The sulfated polysaccharide fucoidan displays excellent anticancer properties with low toxicity in many kinds of cancers. However, its detailed pharmacological effect and mechanism of action in gastric carcinoma remains unclear. In this study, we found that fucoidan could suppress gastric cancer (GC) cell growth, as well as cell migration and invasion. A cytokine expression screen demonstrated that transforming...

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Identifiers

PMID: 31742327
DOI: 10.1093/glycob/cwz097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.