Article
High-throughput genotyping of a full voltage-gated sodium channel gene via genomic DNA using target capture sequencing and analytical pipeline MoNaS to discover novel insecticide resistance mutations.
PLoS neglected tropical diseases - 1 Nov 2019
Itokawa Kentaro, Sekizuka Tsuyoshi, Maekawa Yoshihide, Yatsu Koji, Komagata Osamu, Sugiura Masaaki, Sasaki Tomonori, Tomita Takashi, Kuroda Makoto, Sawabe Kyoko, Kasai Shinji
Abstract excerpt
In insects, the voltage-gated sodium channel (VGSC) is the primary target site of pyrethroid insecticides. Various amino acid substitutions in the VGSC protein, which are selected under insecticide pressure, are known to confer insecticide resistance. In the genome, the VGSC gene consists of more than 30 exons sparsely distributed across a large genomic region, which often exceeds 100 kbp. Due to this complex...
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