Rare Genetic Variants Associated With Sudden Cardiac Death in Adults.

doi:10.1016/j.jacc.2019.08.1060

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Article

Rare Genetic Variants Associated With Sudden Cardiac Death in Adults.

Journal of the American College of Cardiology - 26 Nov 2019

Khera Amit V, Mason-Suares Heather, Brockman Deanna, Wang Minxian, VanDenburgh Martin J, Senol-Cosar Ozlem, Patterson Candace, Newton-Cheh Christopher, Zekavat Seyedeh M, Pester Julie, Chasman Daniel I, Kabrhel Christopher, Jensen Majken K, Manson JoAnn E, Gaziano J Michael, Taylor Kent D, Sotoodehnia Nona, Post Wendy S, Rich Stephen S, Rotter Jerome I, Lander Eric S, Rehm Heidi L, Ng Kenney, Philippakis Anthony, Lebo Matthew, Albert Christine M, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Sudden cardiac death occurs in ∼220,000 U.S. adults annually, the majority of whom have no prior symptoms or cardiovascular diagnosis. Rare pathogenic DNA variants in any of 49 genes can pre-dispose to 4 important causes of sudden cardiac death: cardiomyopathy, coronary artery disease, inherited arrhythmia syndrome, and aortopathy or aortic dissection. OBJECTIVES: This study assessed the prevalence of...

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PMID: 31727422
DOI: 10.1016/j.jacc.2019.08.1060
PMCID: PMC7067308

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