Article
Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers.
Nature communications - 13 Nov 2019
Gopal Priyanka, Sarihan Elif Irem, Chie Eui Kyu, Kuzmishin Gwendolyn, Doken Semihcan, Pennell Nathan A, Raymond Daniel P, Murthy Sudish C, Ahmad Usman, Raja Siva, Almeida Francisco, Sethi Sonali, Gildea Thomas R, Peacock Craig D, Adams Drew J, Abazeed Mohamed E
Abstract excerpt
Molecular determinants governing the evolution of tumor subclones toward phylogenetic branches or fixation remain unknown. Using sequencing data, we model the propagation and selection of clones expressing distinct categories of BRAF mutations to estimate their evolutionary trajectories. We show that strongly activating BRAF mutations demonstrate hard sweep dynamics, whereas mutations with less pronounced...
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