Article
Novel DDX41 variants in Thai patients with myeloid neoplasms.
International journal of hematology - 1 Feb 2020
Polprasert Chantana, Takeda June, Niparuck Pimjai, Rattanathammethee Thanawat, Pirunsarn Arunrat, Suksusut Amornchai, Kobbuaklee Sirorat, Wudhikarn Kitsada, Lawasut Panisinee, Kongkiatkamon Sunisa, Chuncharunee Suporn, Songserm Kritanan, Phowthongkum Prasit, Bunworasate Udomsak, Nannya Yasuhito, Yoshida Kenichi, Makishima Hideki, Ogawa Seishi, Rojnuckarin Ponlapat
Abstract excerpt
Germline DDX41 mutations were recently reported to cause MDS/AML and donor-derived leukemia after transplantation. While previously described in Western countries, DDX41 variants have not been reported in a Southeast Asian population. We performed targeted sequencing of blood or bone marrow samples from 109 Thai patients with myeloid malignancies. Among the 109 patients (75 MDS, 8 MPN, 11 MDS/MPN and 15 AML), the...
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