Sirtuin 3 deficiency does not impede digit regeneration in mice.

doi:10.1038/s41598-019-52921-z

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Article

Sirtuin 3 deficiency does not impede digit regeneration in mice.

Scientific reports - 11 Nov 2019

Busse Emily, Simkin Jennifer, Marrero Luis, Stewart Kennon, Brunauer Regina, Muneoka Ken, Guntur Anyonya, Lacey Michelle, Sammarco Mimi

Abstract excerpt

The mitochondrial deacetylase sirtuin 3 (SIRT3) is thought to be one of the main contributors to metabolic flexibility-promoting mitochondrial energy production and maintaining homeostasis. In bone, metabolic profiles are tightly regulated and the loss of SIRT3 has deleterious effects on bone volume in vivo and on osteoblast differentiation in vitro. Despite the prominent role of this protein in bone stem cell...

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Identifiers

PMID: 31712596
DOI: 10.1038/s41598-019-52921-z
PMCID: PMC6848098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.